Uremic toxin retention on acute kidney injury

Uremic toxin retention on acute kidney injury: Preliminary studies are running at our unit in patients with septic AKI. Based on this, it is clear that when serum creatinine increases in AKI, indoxyl sulfate and p-cresyl sulfate also tend to rise, but less consistently than in chronic kidney disease (CKD). Correlation of concentration of these two compounds to serum creatinine is virtually absent, in contrast to CKD. These data suggest that in AKI, more than in CKD, other factors than renal failure per se interfere with concentration of protein bound uremic toxins.
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